Pregnenolone is supposed to turn into all the steroid hormones, not just estrogen. It’s supposed to be able to turn into testosterone. It’s supposed to turn into cortisone. It’s supposed to turn into aldosterone,” says Dr. Jonathan Wright, MD, from Harvard and The University of Michigan, and author of Natural Medicine, Optimal Wellness: The Patient’s Guide to Health and Healing

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Dr. Wright found, however, two patients, who were each fit athletic males taking 100 mg of pregnenolone, their estrogen increased three times the normal male range while all the other steroid hormones remained within the normal range. These patients were independent of each other and over a year apart in findings. Their levels were tested through a 24-hour urine test.

When it occurred with the first patient they removed all the pregnenolone and the results were remarkable. “He found out he couldn’t take more than 15-20 mg of pregnedalone a day or his estrogens went too high,” Dr. Wright said.

When a woman came in, after taking the same amount of pregnenolone, feeling great like she was on top of the world, they did a 24 hour urine test. Dr. Wright says, “Her cortisol was double normal. In her case (pregnenolone) was metabolizing into cortisol and cortisone.”

Dr. Write says her reaction was a steroid high. He says, “A steroid high means if you take too much cortisol for a while we really feel good (too good). With that much cortisol circulating in your body, even if it came from pregnenolone, it’s going to do all the things that too much cortisol does to you: osteoporosis, high blood pressure and higher probability of ulcers.”

Cure Zone says, “Pregnenolone is a pro-hormone used by the body to produce other steroid hormones, such as testosterone, estrogens, progesterone, cortisone, and many others.” They go on to say, “Before it was pushed aside by the promotion of other hormones, pregnenolone had been shown to have a wide range of beneficial actions for people who were sick or under stress. These included ameliorating arthritis, countering fatigue, and generally improving the quality of life.”

Dr. Mercola says, “Pregnenolone, like DHEA, is a steroidal hormone manufactured in the body. Pregnenolone is a precursor hormone synthesized from cholesterol, principally in the adrenal glands, but also in the liver, skin, brain, testicles, ovaries, and retina of the eyes.”

Click here for a clean DHEA, which shows better results taken in low doses mucosally.

Click here for a clean pregnenolone option that, unlike others, contains no starchy fillers which feed bad bacteria in the gut.

PLOS.org, a scientific publication, says, “Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA a receptor signaling by its metabolites. It has been shown that the level of pregnenolone is altered in certain brain areas of schizophrenic patients, and clozapine enhances pregnenolone in the CNS in rats, suggesting that pregnenolone could be used to treat certain symptoms of schizophrenia.”

GABA, an amino acid that counteracts anxiety, nervousness and insomnia, assists inhibitory neurotransmitters, plus N-acytyl L-tyrosine, a precursor of norepinephrine and is best taken sublingually, the capsule dumped out under the tongue, so that it immediately enters the blood stream. Click here for a clean source of GABA.


Pregnenolone, also shows remarkable effects on cognition, anxiety and depression [read here], [read more here], [read more here], [read more here], [read more here], [read more here].

PLOS.org says, “As a therapeutic agent for schizophrenia (pregnenolone has) been encouraging to date, showing increases in attention, verbal and working memory, and decreases in negative symptoms.” [read more here], [and here].

Cure Zone says, “In the 1950s, however, a raft of new stimulants, painkillers and anti-inflammatories hit the market, and pregnenolone simply got swept into the backwaters of the pharmaceutical world as the medical profession got caught up in the excitement of new drugs and the money they bring in. It was later discovered that the long-term use of these newer drugs led to serious side effects, but by then pregnenolone had become an unfashionable research topic.”

The American Cancer Society praises the positive accolaides of pregnenolone referencing studies in mice with greatly improved memory while on pregnenolone but says, “High doses may cause aggressiveness, irritability, trouble sleeping, and the growth of body or facial hair on women. It also may stop menstruation and lower the levels of HDL, or “good,” cholesterol, which could raise the risk of heart disease. Other possible side effects include acne, heart rhythm problems, liver problems, loss of hair from the scalp, and oily skin.”

Because of the osteoporosis, high blood pressure and higher probability of ulcers Dr. Wright says, “No, I don’t use pregnenolone. I usually caution those who feel it helps their memory to do one of two things. Either limit it to 10-20 mg a day or take more and go get a test that shows if it’s OK to you.”

Too much pregnenolone responds as if the body is stressed permanently and will eventually run you down depleting you.

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